As for never giving up, the few times that you manage an unbelievable comeback can be worth not giving up all the other times. However, if you're no longer having fun, then you might as well surrender, since the point of the (well, any) game is to have fun.
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The first time I watched that video I was like "HOLY **** DID DIAGO JUST DO THAT"
There's always a chance to come back as long as you're doing reasonably well.