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AP Rune Setups - Your favorite?

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Hey folks,

I'm looking to diversify my Runebook a bit, and am wondering if people who've spent a lot of time playing with AP-Rune builds would share their favorite combinations. What's your favorite AP rune setup for champs early game?

I have had the classic 3x Health Quint, 9x MPen Mark, 9x ManaRegen Seal, 9x CooldownRedux Glyph for ages. I've seen some beastly nunu / karthus / vlad setups that basically go pure AP early.

Do people use...
Glyphs - flat AP or scaling AP? How's that work out for you?
Seals - flat AP or scaling AP?
Quint - flat AP or scaling AP instead of flat HP? Or MR pen?