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I had a weird bug earlier where I couldn't save any item sets. The client would freeze when I tried to save. When I went on LoL later all my item sets had completely disappeared. It's really annoying because I had an item set for each champion I was playing. The client doesn't freeze when I save now, but I don't know if item sets are stable enough for me to mess with them.
Mac Mini mid 2010 - Macmini4,1
2.4 GHz Intel Core 2 Duo
NVIDIA GeForce 320M 256 MB
4 GB 1067 MHz DDR3