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Did you read my post? Running a mix of flat apen and mpen gives you the exact same numbers as a set of hybrid pen marks and quints, though you lose 3 glyph slots. So it is better of course, but it costs ~13500 IP for those more efficient runes. Individual milage will vary of course, but I don't have time to drop 2 months of IP grind to gain back a few point of mres/CDR of whatever you were running in your glyph slots.