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Start at level 3, disable Mejai's, Occult, Leviathan, Warmog's and Bloodthirster. Keep Wriggle's Lantern (due to still having a jungle). Banshee's Veil instead of Odyn's Veil. Passive mana regeneration, gold gain, experience gain, etc. Dominion-style respawn timers.
At the moment Twisted Treeline feels like the exact opposite of Dominion (in terms of the features it tries to replicate from Summoner's Rift): it stresses snowballing and lacks true comeback potential (due to how difficult gold-gain is when you're losing on this particular map).
Fix the pathfinding in the blue base that has the minions walk on to the fountain.