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I'm still working on my own runepage, but I'm usually playing Anivia, and (almost) always thrown mid, so I've had a lot of practice. I usually do OK but I haven't faced every champion yet, and am not fluent in everything everyone does - so a champ I've never seen before puts me at a disadvantage. Keep moving, never sit for long (Anivia is a SLOW bird!) or you'll be a sitting duck. Watch out for early ganks and you should be OK. Another thing to keep in mind is that if you're facing off against a carry (Ashe comes to mind)...I'm eventually outclassed because Anivia is not a carry - the best I can do late is hold them off without help.