NOT karthus. That penta is so gimmicky and os chance based. Your best odds are with a fed AD carry or akali. Vayne would be my recommendation
Vayne was my first, second and third.
Wait for team fight, let everyone blow their ult's.
Press R, Q and auto attack and win.
Morgana. Every one forgets about her...Run her with Galios ult..and it's GG PENTAKILL
Saw an Annie that wasn't being focused in a teamfight pull it off pretty easily actually.
Nothing beats Noc. Ive had a quadra and penta in 1 game and another penta nxt game
Cheaply, Karthus. With skill, any champion.
The only one I've witnessed in a normal game was done by an Amumu. Other team was pretty shocked. We laughed pretty hard as well.
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