Twitch is bad... Riot decided that stealth was OP, nerfed it. Oh eve how I miss you.
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Twitch is very strong and can easily get early game kills when laning with someone like amumu. His only weakness is his extreme squishiness.
Defensive Item that suits the game.
Infinity Edge (selling Doran's Blade)
He is OP int he sense that even if people flash away, Expunge still kills them.Just try to use expunge to "Kill Secure". Laning with someone with a stun is pretty good for him. If you have to, go mid with him, but i don't...Mages liek annie murder you.
A handy trick is to get Oracle elixars to kill their vision wards. and if they get oracle elixars, kill them asap. Also use ur ult if people are trying to recall and are pretty low, by the time they realise theyr getting hit, they would at least have 3 stacks on them and a quick expunge to win.
GL and dont forget, a fed Twitch is terribly hard to kill.