If the Nexus didn't impair his regeneration, I imagine he could simply out-heal anything anyone did to him.
It doesn't impair healing *cough* mundo *cough*, now if he didn't have the disease on him he would be very, very scary indeed.
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Ya, his disease is pretty much the thing that nerfed him. =/
And yet the disease he has on him gives him his abilities he can use in Summoner's Rift. Read his lore, he actually just learns to live with it for the time being until a cure is found.
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