She should shriek and hiss with pain, the item should turn black and offer her negative stats...because you know, it would be a cool interaction
If Gragas drinks from the Flask, he sobers up and loses ability power.
Shes not a vampire to a holy symbol, she just hates the Solari.
If Vlad builds Mikael's Crucible, he should lose health on activation.
there's tons of opportunity for unique item interactions in league, the same way dota has (void creatures buying Void Staff, Veigar buying Rabadon's Deathcap, etc).
but they haven't added it as yet and i doubt they will in the future.
Unique interactions like that should never be significant enough to actually influence the game.
Maaaaaybe just Diana gets 1 less shield point from Locket. Kind of like Leona's passive and sunglasses.
Anivia should gradually lose health over time when wearing a Sunfire Cape.
If Veigar manages to get 2000AP, the game servers should crash because he's too stronk.
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