I am new to Swain, and a lot of the guides say different things, what do you guys think is the best setup (Runes, masteries, build, skill order, etc.)
w e w e q r
r e w q
spell vamp quints
spell pen reds
Go to solomids guides and try them all until you find one that suits you, there's a couple different popular builds, and they all start with RoA.
In general though, RoA, then tanky AP, like Abyssal, Zhonyas etc.
Also start levelling your W second until you get comfortable enough to hit it often, then switch to maxing Q second (always max E first) because it has increased damage.
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