My ping normally stays at about 80, but sometime around the Nami/S3 patches, my ping stays at 800 - 1k at all times and has made the game just unplayable
Directly after hitting the LoL button, (the screen where you patch), click the Options icon (next to minimize), and disable Peer to Peer Transfer. This worked for me, and now I can play again .
© 2014 Riot Games, Inc. All rights reserved. Riot Games, League of Legends and PvP.net are trademarks, services marks, or registered trademarks of Riot Games, Inc.