I play them both, mostly Kog'Maw AP.
But if I played them both AD, which would be better? And could you give a good build for them?
I prefer Twitch but it depends how good you are at positioning.
My usual build for Twitch is:
Timing of when you buy Guardian Angel can change, and in rare cases you could get Last Whisper before IE.
I've never really been a great Kog'Maw player, although Twitch is by far my favorite ADC. I use the exact same build as Wolfchanter.
Kog'Maw excels at tanks building lots of HP, Twitch excels at shredding tanks that build more MR and Armor than health.
Kog'Maw is used when your team has a ton of tanks and peelers to protect you
Twitch is used to roflstomp bot lane and assassinate in teamfights with that flipping ult of his.
Kog'Maw deals more damage but is easier to kill.
Twitch deals similar damage but has an escape and is a bit more slipper.
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