Younger Clint Eastwood as Graves. With the "man with no name skin"... hint Riot, make it.
Legend of Dr3w
I also said Charlize Theron as Diana...I'm revising that to Riven.
Verne Troyer as Rumble
Dannie DeVito as Teemo
woong as kog'maw
Derpus the Fifth
Justin Bieber as Ezreal
Conan-era Arnold Schwarzenegger as Tryndamere. (tryndamere vs rengar fights would instantly become more epic as well)
Mark Strong as Darius.
Sarah Jessica Parker as Hecarim.
Seth MacFarlane as the voice of Rammus, who would be a CGI character, and Mike Myers as Gragas: 'DEAD SEXAY!'
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