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Chiefly the Offensive or Defensive masteries? I tend to run 21/9/0. But is 9/21/0 better? I'm not too bent on getting Juggernaut because cc reduction is already adequate, in my opinion.
I do wonder, though, if Irelia benefits more from cooldown reduction than an increased damage output (i.e. Armor penetration). Finally, I have 31 ArPen and per level Armor and MR.
What do you guys use? Should I use Health regen per level Seals instead of Armor? How about Damage per level Marks? What about cooldown reduction Glyphs? Normally, I will stick to Mercury's Treads and/or Ninja Tabi, never considering Ionian Boots.