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This is Hannor here to give you a nice tip for Dominion. Using per level runes instead of the flat stat runes can give you a big advantage on the battle field. Many per level runes equal the value of flat runes at level six or level nine. Since level six and level nine are achieved pretty fast, you can get a significant boost for a big chunk of the game.
Also, magic pen can be bought very quickly on the Scar. Combined with the spell penetration mastery and the buff on Dominion, your casters can enjoy other runes in the marks slot. Only try this if you itemize for spell penetration early in your build. Otherwise, magic pen marks are still a must on mages.