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Manamune is an interesting item, and definitely for every champion. In all honesty, I use it as a conditional item. For example, If I'm playing Caitlyn, and I don't have a support champion in the lane with me, I start meki and 2 health pots, instead of dorans. Manamune on Cait or Corki can give you a really strong laning presence, as you can spam your abilities every time they are up, and you get rewarded for it. What it lacks for damage, it makes up for with the ability useage. Later on in the game, you can really pick up some damage if you grab a banshee's, which I consider a staple on many sqishy champs.